Working Toward an Adenoviral Vector Testing Standard

Working toward an adenoviral vector testing standard.

Designing E1 Deleted Adenoviral Vector by Homologous Recombination

Adenoviruses are used extensively to deliver genes into mammalian cells, particularly where there is a requirement for high-level expression of transgene products in cultured cells, or for use as recombinant viral vaccines or in gene therapy. In spite of their usefulness, the construction of adenoviral vectors (AdV) is a cumbersome and lengthy process that is not readily amenable to the generat...

An Adenoviral Vector Based Vaccine for Rhodococcus equi.

Rhodococcus equi is a respiratory pathogen which primarily infects foals and is endemic on farms around the world with 50% mortality and 80% morbidity in affected foals. Unless detected early and treated appropriately the disease can be fatal. Currently, there is no vaccine available to prevent this disease. For decades researchers have endeavoured to develop an effective vaccine to no avail. I...

Toward an Internet standard scheme for subnetting

Adenoviral vector systems for gene therapy

Adenoviral (Ad) vectors are widely used in gene therapies, recombinant viral vaccines, and basic science studies. The vectors can deliver therapeutic genes into cells to recover the lost function of some genes, to enhance the ability of host immune systems, or to increase the sensitivity of cancer cells to chemotherapeutic drugs. Several adenoviral vector systems have been developed: first-gene...